HitPredict

Interactor 1: EDC4 (Q6P2E9)
Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)
Gene: EDC4

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21182203
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1401 Hs			1 530
+	Hs
		369832 EDC4_HUMAN (1-1401): 0: 1319: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1269937 MACF1_HUMAN (908-1276): 1.45e-46: 186: 10.59		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		370715 MACF1_HUMAN (908-1276): 1.45e-46: 186: 10.59		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		974119 DYST_HUMAN (950-1290): 2.23e-12: 74.4: 11.29		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269367 CHAP1_HUMAN (435-998): 6.58e-12: 72.5: 9.91		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1270066 PCLO_HUMAN (526-984): 9.34e-12: 72.5: 8.35		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		510045 MACF1_HUMAN (908-1276): 1.45e-46: 186: 10.59		ERR1_HUMAN (85-497): 1.88e-112: 342: 35.65
+	Hs
		1243831 KMT2C_HUMAN (433-1018): 2.98e-10: 67.5: 10.44		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		377445 PHLB1_HUMAN (561-1267): 1.66e-48: 192: 13.12		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		369446 DYST_HUMAN (950-1290): 2.23e-12: 74.4: 11.29		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370040 KMT2C_HUMAN (433-1018): 2.98e-10: 67.5: 10.44		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370723 CE164_HUMAN (537-1274): 5.04e-10: 66.6: 13.09		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		782578 SRCAP_HUMAN (542-990): 5.81e-12: 73.2: 12.05		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Mm
		101828 F8WI37_MOUSE (445-898): 7.81e-12: 72.8: 12.68		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Mm
		1142676 KMT2C_MOUSE (445-898): 7.87e-12: 72.8: 12.68		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Hs
		782595 KMT2C_HUMAN (433-1018): 2.98e-10: 67.5: 10.44		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Mm
		1142660 KMT2D_MOUSE (445-988): 6.39e-10: 66.3: 10.00		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Hs
		487538 SRCAP_HUMAN (542-990): 5.81e-12: 73.2: 12.05		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487681 CHAP1_HUMAN (435-998): 6.58e-12: 72.5: 9.91		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487596 KMT2C_HUMAN (433-1018): 2.98e-10: 67.5: 10.44		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59