Interactor 1: LRC8B (Q6P9F7)
Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP)
Gene: LRRC8B

Interactor 2: LRC8A (Q8IWT6)
Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1)
Gene: LRRC8A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 28514442, 33961781, 24790029
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_5~LRR_8, LRR_8~LRR_8, Pannexin_like~Pannexin_like
Common GO terms GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0015810 - aspartate transmembrane transport
GO:0034702 - monoatomic ion channel complex
GO:0098656 - monoatomic anion transmembrane transport
and 1 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 803
Hs

1 810
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024