HitPredict

Interactor 1: WDR59 (Q6PJI9)
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
Gene: WDR59

Interactor 2: CAST1 (Q8WTX7)
Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3)
Gene: CASTOR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	26186194, 28514442, 33961781, 35831510, 26972053
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0034198 - cellular response to amino acid starvation GO:1904262 - negative regulation of TORC1 signaling GO:1904263 - positive regulation of TORC1 signaling
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 974 Hs			1 329
+	Hs
		63018 WDR59_HUMAN (1-974): 0: 805: 100.00		CAST2_HUMAN (1-324): 0: 561: 63.50
+	Hs
		1259681 WDR24_HUMAN (3-165): 3.25e-20: 98.7: 12.79		CAST1_HUMAN (1-329): 0: 582: 100.00
+	Hs
		63021 WDR24_HUMAN (3-165): 3.25e-20: 98.7: 12.79		CAST2_HUMAN (1-324): 0: 561: 63.50