HitPredict

Interactor 1: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Interactor 2: PIWL4 (Q7Z3Z4)
Piwi-like protein 4
Gene: PIWIL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 852
+	Hs
		1162519 Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00		PIWL1_HUMAN (15-852): 0: 977: 49.23
+	Hs
		432159 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		PIWL1_HUMAN (15-852): 0: 977: 49.23
+	Hs
		432003 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		PIWL4_HUMAN (1-852): 0: 960: 100.00
+	Mm
		1174807 Q71LX8_MOUSE (1-345): 1.63e-176: 509: 99.71		AGO2_MOUSE (79-845): 0: 916: 21.49
+	Hs
		438614 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AGO2_HUMAN (90-845): 0: 915: 21.78
+	Mm
		432448 HS90A_MOUSE (1-350): 2.76e-173: 501: 84.12		AGO2_MOUSE (79-845): 0: 916: 21.49
+	Hs
		432355 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		AGO2_HUMAN (90-845): 0: 915: 21.78
+	Hs
		438615 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AGO1_HUMAN (88-837): 0: 902: 21.89
+	Hs
		438537 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AGO3_HUMAN (84-845): 0: 900: 21.03
+	Hs
		1162514 Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00		PIWL2_HUMAN (2-852): 0: 898: 35.10
+	Hs
		432356 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		AGO1_HUMAN (88-837): 0: 902: 21.89
+	Hs
		432271 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		AGO3_HUMAN (84-845): 0: 900: 21.03
+	Hs
		432088 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		PIWL2_HUMAN (2-852): 0: 898: 35.10
+	Dm
		365460 HSP83_DROME (8-350): 1.73e-170: 493: 79.88		Q32KD4_DROME (9-837): 0: 902: 19.65
+	At
		138329 HS903_ARATH (10-349): 6.08e-158: 460: 67.16		AGO1_ARATH (8-846): 0: 934: 19.62
+	Hs
		438545 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AGO4_HUMAN (82-844): 0: 883: 20.81
+	Hs
		432278 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		AGO4_HUMAN (82-844): 0: 883: 20.81
+	Dm
		365480 HSP83_DROME (8-350): 1.73e-170: 493: 79.88		PIWI_DROME (18-852): 0: 783: 32.90
+	Dm
		365462 HSP83_DROME (8-350): 1.73e-170: 493: 79.88		AGO3_DROME (60-852): 0: 779: 34.76
+	Dm
		365485 HSP83_DROME (8-350): 1.73e-170: 493: 79.88		AGO2_DROME (98-837): 0: 617: 20.95