HitPredict

Interactor 1: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Interactor 2: AURKB (Q96GD4)
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Gene: AURKB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 344
+	Hs
		437928 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AKT2_HUMAN (3-343): 1.2e-140: 408: 26.91
+	Hs
		431573 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		AKT2_HUMAN (3-343): 1.2e-140: 408: 26.91
+	Hs
		438633 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AKT3_HUMAN (3-343): 2.05e-138: 403: 28.05
+	Mm
		513660 HS90B_MOUSE (1-345): 1.63e-176: 509: 99.71		AKT1_MOUSE (3-343): 1.38e-137: 400: 29.10
+	Hs
		1162538 Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00		AKT3_HUMAN (3-343): 2.05e-138: 403: 28.05
+	Bt
		964601 HS90B_BOVIN (1-345): 1.88e-175: 506: 99.71		AKT1_BOVIN (3-343): 5.97e-138: 402: 29.38
+	Hs
		437927 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Rn
		812703 HS90A_RAT (1-350): 4.7e-174: 503: 84.40		AKT1_RAT (3-343): 1.22e-137: 400: 28.81
+	Hs
		431572 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Hs
		438430 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Hs
		437870 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KAPCA_HUMAN (36-342): 1.66e-134: 388: 26.18
+	Hs
		160340 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89
+	Hs
		437898 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		437900 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KAPCB_HUMAN (36-342): 2.47e-133: 385: 26.50
+	Hs
		431511 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		KAPCA_HUMAN (36-342): 1.66e-134: 388: 26.18
+	Hs
		438629 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AURKC_HUMAN (35-337): 4.3e-133: 383: 75.91
+	Hs
		160336 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89
+	Hs
		431537 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		431538 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		KAPCB_HUMAN (36-342): 2.47e-133: 385: 26.50
+	Hs
		70435 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		B2RB89_HUMAN (36-342): 2.47e-133: 385: 26.50