HitPredict

Interactor 1: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Interactor 2: Q96II5 (Q96II5)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Gene: ARAF

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 609
+	Hs
		437832 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		ARAF_HUMAN (1-609): 0: 581: 96.89
+	Hs
		431459 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		ARAF_HUMAN (1-609): 0: 581: 96.89
+	Hs
		373549 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		RAF1_HUMAN (6-609): 0: 536: 59.64
+	Hs
		374409 Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00		RAF1_HUMAN (6-609): 0: 536: 59.64
+	Hs
		373543 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		RAF1_HUMAN (6-609): 0: 536: 59.64
+	Hs
		437860 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		BRAF_HUMAN (3-607): 5.85e-180: 529: 56.52
+	Hs
		431496 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		BRAF_HUMAN (3-607): 5.85e-180: 529: 56.52
+	Gg
		513713 HS90A_CHICK (1-350): 2.1e-173: 501: 85.31		BRAF_CHICK (3-607): 4.03e-177: 522: 55.86
+	Rn
		88624 HS90A_RAT (1-350): 4.7e-174: 503: 84.40		D3ZHL1_RAT (50-608): 1.22e-124: 390: 25.54
+	Hs
		438332 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KSR1_HUMAN (50-609): 8.25e-118: 373: 24.56
+	Hs
		433218 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		YES_HUMAN (292-571): 7.06e-104: 326: 31.34
+	Hs
		437847 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		SRC_HUMAN (285-571): 4.29e-104: 326: 30.24
+	Hs
		431433 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		YES_HUMAN (292-571): 7.06e-104: 326: 31.34
+	Hs
		431481 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		SRC_HUMAN (285-571): 4.29e-104: 326: 30.24
+	Hs
		438285 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KSR2_HUMAN (306-587): 3.21e-45: 174: 36.30
+	Hs
		1162501 Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00		KSR2_HUMAN (306-587): 3.21e-45: 174: 36.30
+	Hs
		411949 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		FYN_HUMAN (306-571): 1.8e-37: 148: 33.46
+	Hs
		437967 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		FRK_HUMAN (306-571): 1.37e-36: 145: 33.70
+	Hs
		411945 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		FYN_HUMAN (306-571): 1.8e-37: 148: 33.46
+	Hs
		431627 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		FRK_HUMAN (306-571): 1.37e-36: 145: 33.70