HitPredict

Interactor 1: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Interactor 2: SEC12 (Q9HCU5)
Guanine nucleotide-exchange factor SEC12 (Prolactin regulatory element-binding protein)
Gene: PREB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 351 Hs			1 417
+	Hs
		438547 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		SEC12_HUMAN (1-417): 1.75e-106: 322: 100.00
+	Hs
		432279 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		SEC12_HUMAN (1-417): 1.75e-106: 322: 100.00
+	Hs
		438048 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		WDR5_HUMAN (29-269): 4.37e-37: 139: 9.27
+	Hs
		437971 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		LIS1_HUMAN (251-411): 1.39e-30: 123: 12.43
+	Hs
		431630 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		LIS1_HUMAN (251-411): 1.39e-30: 123: 12.43
+	Cr
		65491 A8J1U1_CHLRE (9-349): 1.63e-165: 480: 66.37		MUT11_CHLRE (249-393): 4.89e-26: 110: 15.86
+	Hs
		152851 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		APAF_HUMAN (139-354): 2.01e-15: 80.7: 19.73
+	Hs
		538184 ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54		WDR5_HUMAN (29-269): 4.37e-37: 139: 9.27
+	Hs
		538141 ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54		LIS1_HUMAN (251-411): 1.39e-30: 123: 12.43
+	Sc
		366167 HSP82_YEAST (11-350): 7.63e-148: 435: 66.86		TAF5_YEAST (11-215): 2.37e-12: 70.6: 8.33
+	Ca
		483034 HSP90_CANAL (9-350): 9.16e-144: 424: 64.14		TUP1_CANAL (137-394): 1.31e-15: 80.7: 17.15
+	Sc
		543602 HSC82_YEAST (13-350): 9.86e-147: 432: 65.19		TAF5_YEAST (11-215): 2.37e-12: 70.6: 8.33
+	Hs
		152853 ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54		APAF_HUMAN (139-354): 2.01e-15: 80.7: 19.73