HitPredict

Interactor 1: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Interactor 2: AKT3 (Q9Y243)
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Gene: AKT3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 479
+	Hs
		438633 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AKT3_HUMAN (1-479): 0: 589: 100.00
+	Mm
		513660 HS90B_MOUSE (1-345): 1.63e-176: 509: 99.71		AKT1_MOUSE (1-477): 0: 562: 82.08
+	Hs
		437928 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AKT2_HUMAN (1-479): 0: 561: 75.78
+	Bt
		964601 HS90B_BOVIN (1-345): 1.88e-175: 506: 99.71		AKT1_BOVIN (1-476): 0: 561: 81.84
+	Hs
		437927 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Rn
		812703 HS90A_RAT (1-350): 4.7e-174: 503: 84.40		AKT1_RAT (1-477): 0: 561: 81.88
+	Hs
		437869 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KPCA_HUMAN (13-476): 6.53e-152: 449: 36.75
+	Hs
		437907 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KPCL_HUMAN (110-476): 8.45e-151: 447: 41.73
+	Hs
		438085 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KPCE_HUMAN (52-473): 1.57e-148: 443: 41.41
+	Hs
		408529 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KPCB_HUMAN (13-476): 3.8e-149: 442: 36.94
+	Hs
		437905 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KS6B1_HUMAN (89-477): 4.14e-149: 437: 38.68
+	Hs
		438094 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KPCT_HUMAN (85-479): 8.26e-147: 437: 39.39
+	Hs
		438422 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		SGK3_HUMAN (61-479): 4.68e-149: 436: 42.35
+	Hs
		438585 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KS6B2_HUMAN (105-477): 1.09e-148: 434: 40.05
+	Hs
		116958 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		116956 HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		438541 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		SGK2_HUMAN (117-474): 5.54e-146: 423: 48.07
+	Hs
		438193 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KS6A1_HUMAN (54-459): 5.85e-103: 325: 21.91
+	Hs
		438011 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KS6A3_HUMAN (146-418): 7.07e-101: 320: 28.52
+	Hs
		437962 HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00		KPCI_HUMAN (118-473): 3.27e-101: 317: 43.94