HitPredict

Interactor 1: TRAF7 (Q6Q0C0)
E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)
Gene: TRAF7

Interactor 2: M4K3 (Q8IVH8)
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)
Gene: MAP4K3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 670 Hs			1 894
+	Hs
		1163057 TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00		M4K5_HUMAN (1-894): 0: 940: 65.41
+	Hs
		1272883 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		M4K1_HUMAN (6-893): 0: 782: 39.19
+	Dm
		1213409 NLE_DROME (379-669): 1.1e-71: 242: 21.20		AKT1_DROME (9-346): 6.87e-130: 405: 24.28
+	Hs
		682082 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		AKT1_HUMAN (6-341): 6.7e-134: 410: 23.70
+	Dm
		218248 O44382_DROME (181-591): 3.08e-62: 217: 14.77		AKT1_DROME (9-346): 6.87e-130: 405: 24.28
+	Dm
		1213390 Q9VDE3_DROME (181-591): 1.74e-61: 215: 14.77		AKT1_DROME (9-346): 6.87e-130: 405: 24.28
+	Hs
		1023143 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		STK4_HUMAN (10-288): 2.22e-119: 373: 46.43
+	Hs
		1023136 FBW1B_HUMAN (181-586): 1.61e-59: 210: 15.51		STK4_HUMAN (10-288): 2.22e-119: 373: 46.43
+	Hs
		681967 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		AKT1_HUMAN (6-341): 6.7e-134: 410: 23.70
+	Hs
		1027457 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		STK3_HUMAN (10-288): 2.29e-117: 368: 45.36
+	Hs
		1027451 FBW1B_HUMAN (181-586): 1.61e-59: 210: 15.51		STK3_HUMAN (10-288): 2.29e-117: 368: 45.36
+	Hs
		1027412 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		STK3_HUMAN (10-288): 2.29e-117: 368: 45.36
+	Hs
		1038897 WDR5B_HUMAN (100-464): 4.85e-24: 105: 11.73		KCC2B_HUMAN (14-543): 1.02e-128: 404: 19.07
+	Dm
		1249839 Q9VDE3_DROME (181-591): 1.74e-61: 215: 14.77		HIPPO_DROME (12-288): 7.36e-72: 251: 44.25
+	Mm
		949357 TBL1R_MOUSE (424-669): 4.14e-51: 187: 19.64		TNIK_MOUSE (6-290): 5.69e-73: 264: 48.32
+	Hs
		324857 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		M4K4_HUMAN (8-290): 6.77e-67: 245: 47.28
+	Dm
		1249851 FBXW7_DROME (10-475): 2.16e-34: 142: 13.09		HIPPO_DROME (12-288): 7.36e-72: 251: 44.25
+	Hs
		793038 LIS1_HUMAN (140-426): 1.68e-23: 105: 10.82		TNIK_HUMAN (6-290): 6.53e-73: 264: 48.32
+	Mm
		949365 TAF5_MOUSE (161-427): 2.56e-21: 100: 11.23		TNIK_MOUSE (6-290): 5.69e-73: 264: 48.32