HitPredict

Interactor 1: TRAF7 (Q6Q0C0)
E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)
Gene: TRAF7

Interactor 2: FBW1B (Q9UKB1)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: FBXW11

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25900982
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0016567 - protein ubiquitination
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 670 Hs			1 542
+	Hs
		1356371 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		1356360 FBW1B_HUMAN (181-586): 1.61e-59: 210: 15.51		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		1377151 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		1163001 TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00		TRAF7_HUMAN (353-522): 1.18e-28: 122: 27.17
+	Hs
		1281292 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29
+	Dm
		1363645 Q9VDE3_DROME (181-591): 1.74e-61: 215: 14.77		Q9VDE3_DROME (320-537): 1.77e-57: 201: 30.32
+	Hs
		1074780 TAF5_HUMAN (98-669): 5.6e-83: 280: 14.17		TAF5_HUMAN (352-541): 4.24e-21: 99.2: 19.39
+	Sc
		630844 NLE1_YEAST (380-669): 2.43e-72: 244: 23.53		NLE1_YEAST (160-305): 3.11e-24: 108: 15.89
+	Hs
		792935 LIS1_HUMAN (140-426): 1.68e-23: 105: 10.82		LIS1_HUMAN (276-542): 4.94e-75: 245: 28.43
+	Mm
		925836 LIS1_MOUSE (140-426): 1.46e-23: 105: 10.82		LIS1_MOUSE (276-542): 3.56e-75: 245: 28.43
+	Hs
		1356571 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		FBXW2_HUMAN (357-517): 4.14e-24: 106: 27.59
+	Hs
		1281468 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		FBXW2_HUMAN (357-517): 4.14e-24: 106: 27.59
+	Dm
		1358859 FBXW7_DROME (10-475): 2.16e-34: 142: 13.09		WDS_DROME (118-309): 1.33e-29: 121: 16.92
+	Hs
		903418 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		WDR5_HUMAN (80-265): 5.44e-16: 81.1: 11.92
+	Hs
		903551 NLE1_HUMAN (119-503): 2.65e-45: 170: 13.81		WDR5_HUMAN (80-265): 5.44e-16: 81.1: 11.92
+	Hs
		1346954 NLE1_HUMAN (119-503): 2.65e-45: 170: 13.81		NLE1_HUMAN (125-224): 6.61e-09: 60.3: 6.00
+	Hs
		1240442 POC1B_HUMAN (507-669): 1.96e-36: 144: 17.06		POC1A_HUMAN (145-308): 4.51e-14: 76: 17.26
+	Hs
		792949 LIS1_HUMAN (140-426): 1.68e-23: 105: 10.82		WDR5_HUMAN (80-265): 5.44e-16: 81.1: 11.92
+	Hs
		903349 WDR5B_HUMAN (100-464): 4.85e-24: 105: 11.73		WDR5_HUMAN (80-265): 5.44e-16: 81.1: 11.92