HitPredict

Interactor 1: NEB2 (Q6R891)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: Ppp1r9b

Interactor 2: ACTN2 (Q9JI91)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	30562941, 20124353, 28634551
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization GO:0030175 - filopodium GO:0030864 - cortical actin cytoskeleton GO:0044325 - transmembrane transporter binding and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 817 Mm			1 894
+	Rn
		192529 NEB2_RAT (1-817): 2.42e-118: 379: 98.90		ACTN1_RAT (10-894): 0: 677: 80.00
+	Mm
		1163959 NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00		ACTN1_MOUSE (10-894): 0: 672: 79.78
+	Hs
		725691 NEB2_HUMAN (1-817): 5.5e-113: 365: 95.84		ACTN2_HUMAN (1-894): 0: 666: 99.22
+	Rn
		88555 NEB2_RAT (1-817): 2.42e-118: 379: 98.90		D3ZCV0_RAT (20-894): 0: 649: 98.97
+	Mm
		885082 NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00		ACTN4_MOUSE (18-894): 0: 632: 78.01
+	Hs
		211646 NEB2_HUMAN (1-817): 5.5e-113: 365: 95.84		ACTN4_HUMAN (18-894): 0: 635: 78.23
+	Hs
		521581 LNX1_HUMAN (224-773): 4.36e-33: 138: 11.92		ACTN1_HUMAN (10-894): 0: 675: 80.00
+	Mm
		49891 DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04		A1BN54_MOUSE (10-894): 0: 677: 80.68
+	Hs
		725649 DLG1_HUMAN (80-763): 3.75e-33: 139: 11.22		ACTN2_HUMAN (1-894): 0: 666: 99.22
+	Hs
		725643 DLG4_HUMAN (438-714): 1.14e-29: 127: 16.03		ACTN2_HUMAN (1-894): 0: 666: 99.22
+	Hs
		993277 LNX1_HUMAN (224-773): 4.36e-33: 138: 11.92		ACTN3_HUMAN (25-894): 0: 652: 80.81
+	Hs
		211617 LNX1_HUMAN (224-773): 4.36e-33: 138: 11.92		ACTN4_HUMAN (18-894): 0: 635: 78.23
+	Mm
		885081 DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04		ACTN4_MOUSE (18-894): 0: 632: 78.01
+	Mm
		1143709 NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00		SPTB2_MOUSE (228-770): 9.31e-15: 81.2: 12.48
+	Mm
		1148440 NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00		Q68FG2_MOUSE (249-767): 1.62e-13: 77.4: 12.09
+	Mm
		1112494 NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00		Q3UGX2_MOUSE (254-755): 1.56e-11: 70.8: 12.15
+	Ce
		105571 DLG1_CAEEL (45-815): 3.37e-50: 192: 12.38		Q23158_CAEEL (150-893): 1.73e-14: 80.1: 14.17
+	Ce
		105581 DLG1_CAEEL (45-815): 3.37e-50: 192: 12.38		Q9XVU8_CAEEL (150-893): 3.71e-14: 78.9: 14.46
+	Mm
		1143324 DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04		SPTB2_MOUSE (228-770): 9.31e-15: 81.2: 12.48
+	Ce
		86403 C1P633_CAEEL (279-715): 4.07e-27: 120: 12.28		Q23158_CAEEL (150-893): 1.73e-14: 80.1: 14.17