HitPredict

Interactor 1: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PID~PID, SH2~SH2
Common GO terms GO:0005886 - plasma membrane
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0030971 - receptor tyrosine kinase binding
GO:0035556 - intracellular signal transduction
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 630
Hs

1 594
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Last updated: 15 Jul 2024