HitPredict

Interactor 1: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Interactor 2: GARE1 (Q9H706)
GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)
Gene: GAREM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 630 Hs			1 876
+	Hs
		666174 SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40		GARE1_HUMAN (1-876): 0: 1707: 100.00
+	Hs
		99742 F5H5M1_HUMAN (287-630): 9.1e-90: 283: 100.00		GARE1_HUMAN (1-876): 0: 1707: 100.00
+	Hs
		209170 NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07		GARE1_HUMAN (1-876): 0: 1707: 100.00
+	Hs
		924865 GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48		GARE1_HUMAN (1-876): 0: 1707: 100.00
+	Mm
		1112482 GRB2_MOUSE (520-614): 1.23e-13: 72.2: 30.30		GARE1_MOUSE (1-876): 0: 1682: 91.45
+	Hs
		924662 GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48		GARE2_HUMAN (432-876): 4.97e-46: 180: 35.53