HitPredict

Interactor 1: CLC2A (Q6UVW9)
C-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR)
Gene: CLEC2A

Interactor 2: CLC2D (Q9UHP7)
C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)
Gene: CLEC2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Lectin_C~Lectin_C
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0030246 - carbohydrate binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 174 Hs			1 191
+	Hs
		1129046 COL12_HUMAN (43-174): 2.13e-40: 146: 22.60		CLC2D_HUMAN (1-191): 2.05e-63: 196: 100.00
+	Hs
		1165060 CLC2A_HUMAN (1-174): 1.37e-58: 182: 100.00		CLC2A_HUMAN (28-188): 4.32e-37: 128: 41.72
+	Hs
		1329767 CLC4M_HUMAN (55-171): 2.17e-44: 152: 29.46		CLC4M_HUMAN (72-188): 4.01e-45: 155: 28.68
+	Hs
		1329768 CLC4M_HUMAN (55-171): 2.17e-44: 152: 29.46		CD209_HUMAN (72-188): 5.05e-43: 149: 30.23
+	Hs
		530384 PGCB_HUMAN (40-169): 9.62e-41: 147: 15.28		CSPG2_HUMAN (52-189): 1.21e-42: 154: 20.67
+	Hs
		59764 COL12_HUMAN (43-174): 2.13e-40: 146: 22.60		KLRG2_HUMAN (33-186): 7.9e-44: 152: 28.93
+	Hs
		1342238 CD209_HUMAN (55-171): 4.01e-41: 144: 24.81		CD209_HUMAN (72-188): 5.05e-43: 149: 30.23
+	Hs
		426840 ASGR2_HUMAN (36-172): 4.1e-44: 149: 19.74		CL17A_HUMAN (72-187): 1.27e-40: 142: 31.20
+	Hs
		88112 CLC2A_HUMAN (1-174): 1.37e-58: 182: 100.00		KLRF2_HUMAN (24-189): 3.2e-27: 104: 24.72
+	Hs
		1170205 CL17A_HUMAN (52-170): 2.52e-41: 143: 22.66		CL17A_HUMAN (72-187): 1.27e-40: 142: 31.20
+	Hs
		426865 ASGR2_HUMAN (36-172): 4.1e-44: 149: 19.74		CLC7A_HUMAN (20-187): 5.72e-36: 127: 20.00
+	Mm
		653899 CLC2I_MOUSE (32-169): 1.81e-41: 140: 43.24		KLRBC_MOUSE (10-190): 8.67e-40: 136: 23.23
+	Dr
		60054 A4JYN2_DANRE (40-169): 7.11e-38: 139: 12.50		A4JYN2_DANRE (52-187): 1.19e-36: 136: 18.24
+	Hs
		644653 CLC2D_HUMAN (16-174): 6.01e-43: 143: 41.82		NKG2A_HUMAN (23-188): 8.34e-38: 132: 19.77
+	Hs
		1129021 COL12_HUMAN (43-174): 2.13e-40: 146: 22.60		CL12A_HUMAN (48-191): 1.63e-34: 124: 23.33
+	Hs
		1129031 COL12_HUMAN (43-174): 2.13e-40: 146: 22.60		CLC4F_HUMAN (77-152): 6.03e-26: 105: 33.77