HitPredict

Interactor 1: LRSM1 (Q6UWE0)
E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL)
Gene: LRSAM1

Interactor 2: LRC46 (Q96FV0)
Leucine-rich repeat-containing protein 46
Gene: LRRC46

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_4~LRR_8
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 723 Hs			1 321
+	Hs
		1049984 LRSM1_HUMAN (1-723): 4.35e-103: 333: 100.00		SCRIB_HUMAN (1-224): 6.78e-32: 127: 15.29
+	At
		1352203 Y1723_ARATH (4-478): 3.21e-68: 245: 14.58		BRL2_ARATH (30-320): 1.38e-31: 126: 12.83
+	Hs
		1204014 LRCH3_HUMAN (11-433): 1.03e-53: 199: 19.38		DAA11_HUMAN (17-208): 3.47e-41: 151: 30.46
+	At
		1322950 CEPR1_ARATH (3-479): 1.64e-61: 224: 14.26		BRL1_ARATH (49-312): 4.07e-29: 119: 16.79
+	At
		1378334 BRL2_ARATH (97-554): 8.5e-52: 196: 11.00		BRL2_ARATH (30-320): 1.38e-31: 126: 12.83
+	At
		221776 GSO2_ARATH (8-598): 1.16e-73: 261: 14.36		BAME1_ARATH (197-311): 3.11e-09: 60.3: 12.07
+	Zm
		19443 A0A1D6HD42_MAIZE (1-374): 1.55e-57: 213: 16.67		A0A1D6HD42_MAIZE (135-318): 1.73e-22: 99: 11.35
+	At
		84509 GSO1_ARATH (115-642): 2.85e-48: 186: 13.12		BRL2_ARATH (30-320): 1.38e-31: 126: 12.83
+	At
		84466 GSO1_ARATH (115-642): 2.85e-48: 186: 13.12		ERECT_ARATH (2-246): 3.24e-31: 125: 18.46
+	At
		84511 GSO1_ARATH (115-642): 2.85e-48: 186: 13.12		BRL1_ARATH (49-312): 4.07e-29: 119: 16.79
+	At
		84461 GSO1_ARATH (115-642): 2.85e-48: 186: 13.12		SKM1_ARATH (2-203): 6.8e-25: 107: 19.62
+	At
		84495 GSO1_ARATH (115-642): 2.85e-48: 186: 13.12		IRK_ARATH (113-320): 2.44e-23: 102: 10.85
+	Dm
		1181694 SCRIB_DROME (4-338): 1.89e-47: 184: 23.60		SCRIB_DROME (1-143): 1.63e-23: 103: 15.66
+	At
		84489 GSO1_ARATH (115-642): 2.85e-48: 186: 13.12		BRL3_ARATH (93-320): 1.37e-20: 94.5: 14.62
+	At
		1338953 BRL2_ARATH (97-554): 8.5e-52: 196: 11.00		Y1571_ARATH (169-303): 2.93e-11: 66.4: 10.29
+	At
		1338065 BRL2_ARATH (97-554): 8.5e-52: 196: 11.00		RGI1_ARATH (166-312): 2.04e-10: 63.7: 9.46
+	At
		221786 PEPR2_ARATH (1-382): 1.61e-50: 192: 12.83		BAME1_ARATH (197-311): 3.11e-09: 60.3: 12.07
+	At
		84459 GSO1_ARATH (115-642): 2.85e-48: 186: 13.12		BAME1_ARATH (197-311): 3.11e-09: 60.3: 12.07
+	At
		85103 ERL2_ARATH (162-597): 2.2e-47: 183: 10.83		RGI2_ARATH (201-301): 3.76e-09: 59.9: 10.78
+	At
		99012 ERL2_ARATH (162-597): 2.2e-47: 183: 10.83		RGI4_ARATH (213-320): 5.68e-09: 59.5: 16.51