HitPredict

Interactor 1: I20RB (Q6UXL0)
Interleukin-20 receptor subunit beta (IL-20 receptor subunit beta) (IL-20R-beta) (IL-20RB) (Fibronectin type III domain containing 6) (FNDC6) (IL-20R2)
Gene: IL20RB

Interactor 2: IL20 (Q9NYY1)
Interleukin-20 (IL-20) (Cytokine Zcyto10)
Gene: IL20

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.80	0.799

Property	Details
Experiments	14580208, 11163236, 22232181, 22802649
Identification Methods	molecular sieving, saturation binding, x-ray crystallography, surface plasmon resonance, cross-linking study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	IL10~Interfer-bind, IL10~Tissue_fac
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 311 Hs			1 176
+	Hs
		1166648 I20RB_HUMAN (1-311): 2.71e-109: 321: 100.00		IL19_HUMAN (1-174): 2.98e-75: 224: 40.23
+	Hs
		1022378 I20RB_HUMAN (1-311): 2.71e-109: 321: 100.00		IL24_HUMAN (3-174): 1.33e-60: 188: 31.64
+	Hs
		1348715 I20RA_HUMAN (24-306): 3.6e-69: 226: 20.59		IL20_HUMAN (1-176): 1.46e-69: 210: 100.00
+	Hs
		1236248 I22R1_HUMAN (39-311): 4.91e-49: 173: 14.19		IL20_HUMAN (1-176): 1.46e-69: 210: 100.00
+	Hs
		606845 I10R2_HUMAN (26-304): 6.14e-68: 216: 21.05		IL10_HUMAN (39-173): 3.51e-39: 133: 27.41
+	Mm
		579830 I10R1_MOUSE (34-311): 2.14e-55: 190: 19.02		IL10_MOUSE (39-173): 4.4e-49: 158: 30.37
+	Hs
		606848 I10R1_HUMAN (34-303): 9.16e-57: 194: 21.70		IL10_HUMAN (39-173): 3.51e-39: 133: 27.41
+	Hs
		606839 INAR2_HUMAN (13-279): 6.26e-55: 188: 14.84		IL10_HUMAN (39-173): 3.51e-39: 133: 27.41