HitPredict

Interactor 1: LRIG3 (Q6UXM1)
Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3)
Gene: LRIG3

Interactor 2: LRIG1 (Q96JA1)
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1)
Gene: LRIG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	28514442, 33961781, 23723069
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	I-set~I-set, Ig_3~I-set, I-set~LRR_8, Ig_3~Ig_3, Ig_3~LRR_8, LRR_1~LRR_4, LRR_1~LRR_8, LRR_4~LRR_8, LRR_8~LRR_8, LRR_8~LRRCT
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0031012 - extracellular matrix GO:0032474 - otolith morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1119 Hs			1 1093
+	Hs
		1166667 LRIG3_HUMAN (2-1119): 0: 769: 100.00		LRC4C_HUMAN (41-341): 5.52e-15: 81.6: 26.32
+	Hs
		259500 LRIG3_HUMAN (2-1119): 0: 769: 100.00		LRRN2_HUMAN (699-780): 4.92e-11: 69.1: 28.24
+	At
		84466 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		GSO1_ARATH (6-466): 1.48e-101: 349: 20.99
+	At
		1114685 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		ERL2_ARATH (47-465): 8.34e-102: 345: 21.27
+	At
		1114682 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		ERECT_ARATH (32-466): 3.37e-98: 335: 20.82
+	At
		1114712 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		EMS1_ARATH (15-468): 1.35e-93: 326: 19.07
+	At
		1114706 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		PXL1_ARATH (119-466): 1.13e-81: 290: 20.63
+	At
		1114705 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		FLS2_ARATH (81-500): 7.07e-77: 277: 18.96
+	At
		1338062 RGI1_ARATH (1-397): 1.45e-88: 312: 19.46		EMS1_ARATH (15-468): 1.35e-93: 326: 19.07
+	At
		85352 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		ERL1_ARATH (155-458): 5.89e-58: 219: 17.26
+	At
		221761 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		BAME1_ARATH (163-476): 1.76e-57: 218: 20.51
+	At
		187538 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		PXC3_ARATH (186-441): 5.75e-49: 190: 20.60
+	At
		84451 GSO1_ARATH (24-569): 7.63e-88: 311: 18.66		Y4361_ARATH (118-453): 1.87e-64: 240: 21.83
+	At
		1114702 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		TDR_ARATH (212-458): 5.1e-43: 172: 18.22
+	At
		221789 RGI1_ARATH (1-397): 1.45e-88: 312: 19.46		BAME1_ARATH (163-476): 1.76e-57: 218: 20.51
+	At
		249741 Y1723_ARATH (30-567): 2.56e-89: 313: 17.85		BAME3_ARATH (171-563): 1.08e-52: 203: 17.88
+	At
		249735 RGI1_ARATH (1-397): 1.45e-88: 312: 19.46		BAME3_ARATH (171-563): 1.08e-52: 203: 17.88
+	At
		1114713 ERECT_ARATH (1-610): 7.14e-111: 371: 16.86		BAME2_ARATH (305-448): 4.63e-25: 114: 26.39
+	At
		1352203 Y1723_ARATH (30-567): 2.56e-89: 313: 17.85		BRL2_ARATH (275-442): 4.41e-16: 85.6: 22.60
+	At
		1338065 RGI1_ARATH (1-397): 1.45e-88: 312: 19.46		BRL2_ARATH (275-442): 4.41e-16: 85.6: 22.60