HitPredict

Interactor 1: RSPO2 (Q6UXX9)
R-spondin-2 (Roof plate-specific spondin-2) (hRspo2)
Gene: RSPO2

Interactor 2: LGR4 (Q9BXB1)
Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48)
Gene: LGR4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	25504990, 29752411, 24050775
Identification Methods	pull down, fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Furin-like_2~LRR_8
Common GO terms	GO:0001649 - osteoblast differentiation GO:0030282 - bone mineralization GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 951
+	Hs
		1101906 RSPO1_HUMAN (1-231): 1.3e-63: 200: 41.45		LGR4_HUMAN (22-951): 0: 718: 100.00
+	Hs
		1315144 RSPO3_HUMAN (1-204): 4.84e-55: 179: 48.56		LGR4_HUMAN (22-951): 0: 718: 100.00
+	Hs
		1100838 RSPO4_HUMAN (27-215): 6.55e-48: 160: 46.56		LGR4_HUMAN (22-951): 0: 718: 100.00
+	Hs
		265893 RSPO2_HUMAN (1-243): 1.07e-79: 241: 100.00		LGR5_HUMAN (1-279): 1.21e-37: 154: 27.47
+	Hs
		265892 RSPO1_HUMAN (1-231): 1.3e-63: 200: 41.45		LGR5_HUMAN (1-279): 1.21e-37: 154: 27.47
+	Hs
		411273 INSR_HUMAN (12-160): 1.12e-34: 133: 22.64		PGS2_HUMAN (27-292): 7.13e-29: 121: 32.71
+	Hs
		1191117 FRAS1_HUMAN (35-200): 8.13e-14: 72.6: 19.05		PODN_HUMAN (35-262): 1.88e-30: 130: 28.94
+	Hs
		560488 PCSK6_HUMAN (32-214): 5.97e-14: 72.6: 20.32		TSHR_HUMAN (31-302): 4.28e-16: 85: 20.89