HitPredict

Interactor 1: RSPO2 (Q6UXX9)
R-spondin-2 (Roof plate-specific spondin-2) (hRspo2)
Gene: RSPO2

Interactor 2: ZNRF3 (Q9ULT6)
E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)
Gene: ZNRF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	24050775, 28600110, 25504990, 29752411, 29769720
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Furin-like_2~ZNRF_3_ecto
Common GO terms	GO:0060173 - limb development
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 936
+	Mm
		1131452 RSPO2_MOUSE (1-243): 1.95e-78: 238: 95.89		ZNRF3_MOUSE (56-921): 0: 788: 85.81
+	Hs
		1101909 RSPO1_HUMAN (1-231): 1.3e-63: 200: 41.45		ZNRF3_HUMAN (1-936): 0: 792: 100.00
+	Hs
		1315975 RSPO3_HUMAN (1-204): 4.84e-55: 179: 48.56		ZNRF3_HUMAN (1-936): 0: 792: 100.00
+	Xl
		1117306 RSPO2_XENLA (1-243): 4.5e-76: 232: 83.95		ZNRF3_XENLA (100-916): 5.16e-180: 542: 54.39
+	Hs
		1148106 RSPO2_HUMAN (1-243): 1.07e-79: 241: 100.00		RNF43_HUMAN (42-780): 1.31e-112: 366: 28.76
+	Hs
		1101902 RSPO1_HUMAN (1-231): 1.3e-63: 200: 41.45		RNF43_HUMAN (42-780): 1.31e-112: 366: 28.76
+	Hs
		435537 IGF1R_HUMAN (14-160): 3.61e-34: 131: 24.05		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		435696 IGF1R_HUMAN (14-160): 3.61e-34: 131: 24.05		RN149_HUMAN (46-369): 1.32e-76: 257: 18.86
+	Hs
		435684 IGF1R_HUMAN (14-160): 3.61e-34: 131: 24.05		SYVN1_HUMAN (39-637): 1.81e-50: 190: 15.07