HitPredict

Interactor 1: BCOR (Q6W2J9)
BCL-6 corepressor (BCoR)
Gene: BCOR

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	26496610, 26687479, 27505670, 24981860, 33468080, 16943429, 24457600, 27705803, 22325352
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PUFD~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1755 Hs			1 336
+	Mm
		1208443 BCOR_MOUSE (1-1755): 0: 2352: 88.59		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Hs
		987982 BCOR_HUMAN (1-1755): 0: 2385: 100.00		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		1167299 BCOR_HUMAN (1-1755): 0: 2385: 100.00		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		717948 BCOR_HUMAN (1-1755): 0: 2385: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		718405 BCOR_HUMAN (1-1755): 0: 2385: 100.00		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		1108510 BCOR_HUMAN (1-1755): 0: 2385: 100.00		PCGF3_HUMAN (36-334): 3.56e-44: 153: 18.15
+	Hs
		1167302 BCOR_HUMAN (1-1755): 0: 2385: 100.00		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		1167255 BCOR_HUMAN (1-1755): 0: 2385: 100.00		PCGF5_HUMAN (34-334): 1.89e-39: 141: 15.24
+	Hs
		536889 BCOR_HUMAN (1-1755): 0: 2385: 100.00		TRI27_HUMAN (36-282): 4.98e-37: 141: 16.08
+	Hs
		1125897 BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		1021448 ANK3_HUMAN (1206-1755): 3.54e-78: 290: 12.69		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		987979 BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		1125899 BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		717904 BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		718403 BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		1108508 BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63		PCGF3_HUMAN (36-334): 3.56e-44: 153: 18.15
+	Hs
		1125901 BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		1125882 BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63		PCGF5_HUMAN (34-334): 1.89e-39: 141: 15.24
+	Hs
		310081 TNKS1_HUMAN (1296-1752): 5.7e-75: 277: 13.95		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		310038 TNKS1_HUMAN (1296-1752): 5.7e-75: 277: 13.95		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79