HitPredict

Interactor 1: LMTK1 (Q6ZMQ8)
Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)
Gene: AATK

Interactor 2: PPM1K (Q8N3J5)
Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial)
Gene: PPM1K

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1374 Hs			1 372
+	Hs
		728626 LMTK1_HUMAN (1-1374): 0: 976: 100.00		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		273446 LMTK1_HUMAN (1-1374): 0: 976: 100.00		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		1219428 LMTK2_HUMAN (9-1366): 0: 690: 29.74		PPM1K_HUMAN (1-372): 1.48e-158: 451: 100.00
+	Hs
		1168415 LMTK1_HUMAN (1-1374): 0: 976: 100.00		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		728631 LMTK2_HUMAN (9-1366): 0: 690: 29.74		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		1219443 LMTK2_HUMAN (9-1366): 0: 690: 29.74		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		601473 FGFR2_HUMAN (17-456): 6.43e-126: 412: 19.75		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Zm
		28091 A0A1D6JP48_MAIZE (54-408): 4.26e-125: 395: 19.27		B4FBQ5_MAIZE (89-346): 2.3e-101: 305: 32.57
+	Hs
		273355 FGFR1_HUMAN (28-460): 6.26e-120: 396: 21.00		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		1031152 PTK7_HUMAN (32-391): 2.34e-37: 155: 31.90		PPM1K_HUMAN (1-372): 1.48e-158: 451: 100.00
+	Hs
		169202 MUSK_HUMAN (7-402): 6.06e-121: 400: 25.42		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		411324 INSR_HUMAN (111-395): 4.12e-41: 167: 36.27		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		435562 IGF1R_HUMAN (119-391): 2.65e-38: 159: 34.51		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		665427 EPHA3_HUMAN (12-404): 1.11e-104: 358: 23.74		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		728604 PTK7_HUMAN (32-391): 2.34e-37: 155: 31.90		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		273427 PTK7_HUMAN (32-391): 2.34e-37: 155: 31.90		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		728673 ALK_HUMAN (109-386): 2.69e-32: 139: 32.99		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		273378 RYK_HUMAN (96-403): 1.66e-31: 134: 30.56		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		435754 IGF1R_HUMAN (119-391): 2.65e-38: 159: 34.51		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		1031167 PTK7_HUMAN (32-391): 2.34e-37: 155: 31.90		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06