HitPredict

Interactor 1: SYNE3 (Q6ZMZ3)
Nesprin-3 (KASH domain-containing protein 3) (KASH3) (Nuclear envelope spectrin repeat protein 3)
Gene: SYNE3

Interactor 2: MIB2 (Q96AX9)
E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1)
Gene: MIB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 975 Hs			1 955
+	Hs
		1168566 SYNE3_HUMAN (1-975): 1.69e-66: 243: 100.00		MIB1_HUMAN (11-954): 0: 611: 36.35
+	Hs
		1168740 SYNE3_HUMAN (1-975): 1.69e-66: 243: 100.00		KDIS_HUMAN (250-634): 3.86e-58: 220: 16.88
+	Hs
		1168570 SYNE3_HUMAN (1-975): 1.69e-66: 243: 100.00		ANKH1_HUMAN (705-939): 3.36e-20: 99.1: 12.13
+	Hs
		725139 MYH10_HUMAN (1-826): 4.57e-32: 138: 11.81		ANK2_HUMAN (626-955): 4.16e-50: 195: 16.76
+	Hs
		724782 MYH9_HUMAN (2-697): 2.15e-22: 106: 9.04		ANK2_HUMAN (626-955): 4.16e-50: 195: 16.76
+	Hs
		809198 UTRN_HUMAN (4-702): 5.63e-11: 69.2: 12.03		KDIS_HUMAN (250-634): 3.86e-58: 220: 16.88
+	Hs
		1021458 SPTN4_HUMAN (6-825): 4.17e-18: 92.3: 13.61		ANK3_HUMAN (626-955): 8.41e-49: 191: 15.73
+	Hs
		360612 SPTA1_HUMAN (5-651): 5.81e-17: 88.9: 12.35		ANK1_HUMAN (626-955): 8.19e-47: 185: 14.89
+	Hs
		965102 SPTN1_HUMAN (5-666): 4.38e-13: 76: 9.94		ANK2_HUMAN (626-955): 4.16e-50: 195: 16.76
+	Hs
		965174 MACF1_HUMAN (3-477): 8.96e-13: 75: 12.55		ANK2_HUMAN (626-955): 4.16e-50: 195: 16.76
+	Hs
		164604 SPTN2_HUMAN (5-282): 3.82e-12: 73.1: 13.31		ANK2_HUMAN (626-955): 4.16e-50: 195: 16.76
+	Hs
		1021399 SPTN1_HUMAN (5-666): 4.38e-13: 76: 9.94		ANK3_HUMAN (626-955): 8.41e-49: 191: 15.73
+	Hs
		164611 SPTN2_HUMAN (5-282): 3.82e-12: 73.1: 13.31		ANK3_HUMAN (626-955): 8.41e-49: 191: 15.73
+	Hs
		809108 UTRN_HUMAN (4-702): 5.63e-11: 69.2: 12.03		ANK3_HUMAN (626-955): 8.41e-49: 191: 15.73
+	Mm
		82740 B9EKJ1_MOUSE (27-948): 8.4e-13: 75.3: 9.92		ANK3_MOUSE (640-936): 9.74e-43: 171: 17.45
+	Mm
		561172 SPTN1_MOUSE (5-666): 3.45e-13: 76.4: 9.94		ANK2_MOUSE (675-945): 1.97e-32: 139: 12.67
+	Hs
		1330882 MACF1_HUMAN (3-477): 8.96e-13: 75: 12.55		Q9H4D1_HUMAN (443-669): 7.42e-16: 84.3: 28.57
+	Hs
		883671 MACF1_HUMAN (3-477): 8.96e-13: 75: 12.55		RIPK4_HUMAN (443-669): 1.29e-15: 83.6: 28.57
+	Hs
		862037 SPTN1_HUMAN (5-666): 4.38e-13: 76: 9.94		DAPK1_HUMAN (491-787): 5.06e-14: 79: 24.42
+	Hs
		164586 SPTN2_HUMAN (5-282): 3.82e-12: 73.1: 13.31		DAPK1_HUMAN (491-787): 5.06e-14: 79: 24.42