HitPredict

Interactor 1: SYNE3 (Q6ZMZ3)
Nesprin-3 (KASH domain-containing protein 3) (KASH3) (Nuclear envelope spectrin repeat protein 3)
Gene: SYNE3

Interactor 2: SRBS1 (Q9BX66)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: SORBS1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 975 Hs			1 1292
+	Hs
		724817 MYH9_HUMAN (2-697): 2.15e-22: 106: 9.04		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Hs
		298985 SYNE3_HUMAN (1-975): 1.69e-66: 243: 100.00		SRBS2_HUMAN (516-926): 8.23e-14: 78.7: 14.74
+	Hs
		1045513 SPTN4_HUMAN (6-825): 4.17e-18: 92.3: 13.61		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Rn
		555258 Q6XD99_RAT (7-847): 5.65e-14: 79.1: 15.88		SPTN1_RAT (304-921): 4.41e-58: 223: 13.62
+	Hs
		164614 SPTN2_HUMAN (5-282): 3.82e-12: 73.1: 13.31		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Hs
		522612 MYH7_HUMAN (4-409): 6.25e-10: 65.6: 9.58		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Hs
		360664 SPTN4_HUMAN (6-825): 4.17e-18: 92.3: 13.61		SPTA1_HUMAN (303-1028): 9.45e-45: 180: 9.89
+	Dm
		527098 Q7KV70_DROME (7-745): 3.05e-12: 73.3: 13.74		SPTCA_DROME (304-905): 9.17e-50: 196: 9.98
+	Hs
		360600 SPTA1_HUMAN (5-651): 5.81e-17: 88.9: 12.35		SPTA1_HUMAN (303-1028): 9.45e-45: 180: 9.89
+	Mm
		434793 DMD_MOUSE (3-458): 8.07e-11: 68.8: 11.53		SPTA1_MOUSE (304-899): 7.07e-45: 180: 9.06
+	Hs
		724801 MYH9_HUMAN (2-697): 2.15e-22: 106: 9.04		MYO1E_HUMAN (1089-1290): 2.99e-25: 116: 16.06
+	Hs
		724825 MYH9_HUMAN (2-697): 2.15e-22: 106: 9.04		SRC8_HUMAN (991-1288): 1.92e-23: 108: 13.38
+	Mm
		434800 SPTA1_MOUSE (124-876): 2.06e-27: 122: 12.94		SRBS2_MOUSE (508-926): 2.95e-15: 83.3: 15.18
+	Hs
		298957 MYH9_HUMAN (2-697): 2.15e-22: 106: 9.04		SRBS2_HUMAN (516-926): 8.23e-14: 78.7: 14.74
+	Hs
		1045408 SPTN1_HUMAN (5-666): 4.38e-13: 76: 9.94		SRC8_HUMAN (991-1288): 1.92e-23: 108: 13.38
+	Hs
		1045423 SPTN1_HUMAN (5-666): 4.38e-13: 76: 9.94		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Rn
		192738 SPTN1_RAT (5-666): 3.45e-13: 76.4: 9.94		SRBS2_RAT (508-926): 5.66e-14: 79.4: 15.40
+	Hs
		974083 DYST_HUMAN (1-921): 4.17e-12: 72.9: 9.83		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		1078871 SYNE1_HUMAN (7-941): 2.97e-10: 66.8: 11.22		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		974160 DYST_HUMAN (1-921): 4.17e-12: 72.9: 9.83		ITSN2_HUMAN (1079-1290): 3.39e-12: 73.7: 14.49