HitPredict

Interactor 1: DEFI8 (Q6ZN54)
Differentially expressed in FDCP 8 homolog (DEF-8)
Gene: DEF8

Interactor 2: E2AK4 (Q9P2K8)
eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein)
Gene: EIF2AK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1_1~Pkinase
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 1649
+	Hs
		969084 KPCE_HUMAN (151-250): 8.06e-23: 104: 17.43		KS6A2_HUMAN (634-1044): 1.25e-87: 305: 16.63
+	Hs
		566395 KPCA_HUMAN (151-250): 2.8e-20: 96.3: 16.83		KS6A2_HUMAN (634-1044): 1.25e-87: 305: 16.63
+	Hs
		272841 KPCB_HUMAN (151-269): 6.29e-21: 98.3: 15.00		KS6A4_HUMAN (25-541): 2.75e-72: 260: 13.40
+	Rn
		506703 DGKG_RAT (135-333): 2.17e-37: 148: 16.67		KCC2A_RAT (11-208): 1.51e-29: 126: 12.56
+	Hs
		408702 KPCB_HUMAN (151-269): 6.29e-21: 98.3: 15.00		KCC2A_HUMAN (11-208): 1.52e-29: 126: 12.56
+	Rn
		506713 KPCB_RAT (151-269): 5.86e-21: 98.3: 15.00		KCC2A_RAT (11-208): 1.51e-29: 126: 12.56
+	Rn
		506712 KPCG_RAT (151-270): 1.49e-18: 90.9: 15.70		KCC2A_RAT (11-208): 1.51e-29: 126: 12.56