HitPredict

Interactor 1: RN111 (Q6ZNA4)
E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)
Gene: RNF111

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.815

Property	Details
Experiments	19690564, 19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 994 Hs			1 147
+	Hs
		849348 RN111_HUMAN (1-994): 0: 902: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919758 RN111_HUMAN (1-994): 0: 902: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895821 RN111_HUMAN (1-994): 0: 902: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1169179 RN111_HUMAN (1-994): 0: 902: 100.00		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1169175 RN111_HUMAN (1-994): 0: 902: 100.00		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851828 RN111_HUMAN (1-994): 0: 902: 100.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		896473 RN111_HUMAN (1-994): 0: 902: 100.00		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		1170316 ARK2C_HUMAN (651-994): 2.56e-59: 208: 41.26		UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00
+	Hs
		849350 ARK2C_HUMAN (651-994): 2.56e-59: 208: 41.26		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919759 ARK2C_HUMAN (651-994): 2.56e-59: 208: 41.26		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895822 ARK2C_HUMAN (651-994): 2.56e-59: 208: 41.26		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	At
		96605 F4IQ07_ARATH (489-994): 8.69e-51: 191: 15.91		UBC9_ARATH (1-147): 1.26e-82: 241: 80.27
+	Hs
		1170314 ARK2C_HUMAN (651-994): 2.56e-59: 208: 41.26		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851829 ARK2C_HUMAN (651-994): 2.56e-59: 208: 41.26		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	At
		96610 F4IQ07_ARATH (489-994): 8.69e-51: 191: 15.91		UBC29_ARATH (1-147): 3.11e-79: 232: 76.87
+	At
		715139 RHG1A_ARATH (429-984): 6.11e-47: 181: 16.78		UBC9_ARATH (1-147): 1.26e-82: 241: 80.27
+	At
		715158 RHG1A_ARATH (429-984): 6.11e-47: 181: 16.78		UBC11_ARATH (1-147): 8.34e-83: 241: 79.59
+	At
		715138 Q8VYL4_ARATH (489-994): 1.33e-46: 177: 15.91		UBC9_ARATH (1-147): 1.26e-82: 241: 80.27
+	Hs
		896474 ARK2C_HUMAN (651-994): 2.56e-59: 208: 41.26		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	At
		1258030 Q8VYL4_ARATH (489-994): 1.33e-46: 177: 15.91		UBC29_ARATH (1-147): 3.11e-79: 232: 76.87