HitPredict

Interactor 1: KDM1A (Q6ZQ88)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2)
Gene: KDM1A

Interactor 2: RING2 (Q9CQJ4)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)
Gene: Rnf2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	26206133, 17296600, 22496869
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 853 Mm			1 336
+	Hs
		232457 KDM1A_HUMAN (1-853): 0: 1019: 98.12		RING2_HUMAN (1-336): 2.74e-106: 315: 99.70
+	Hs
		232025 KDM1A_HUMAN (1-853): 0: 1019: 98.12		BRCA1_HUMAN (36-213): 1.88e-33: 132: 25.93
+	Hs
		232473 KDM1A_HUMAN (1-853): 0: 1019: 98.12		TRAF4_HUMAN (42-321): 1.6e-33: 130: 10.49
+	Hs
		232526 KDM1A_HUMAN (1-853): 0: 1019: 98.12		TRI39_HUMAN (30-265): 2.83e-33: 130: 16.81
+	Mm
		1112449 KDM1A_MOUSE (1-853): 0: 998: 100.00		Q3UCL2_MOUSE (40-249): 1.88e-37: 141: 15.71
+	Hs
		66352 A8K2R3_HUMAN (124-853): 0: 864: 99.73		TRI39_HUMAN (30-265): 2.83e-33: 130: 16.81