HitPredict

Interactor 1: SRCAP (Q6ZRS2)
Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)
Gene: SRCAP

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	10347196, 11581372
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0004402 - histone acetyltransferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription and 1 others more... GO:0016604 - nuclear body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3230 Hs			1 2442
+	Hs
		998826 SRCAP_HUMAN (1-3230): 0: 1210: 100.00		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		1172508 Q6ZTM8_HUMAN (1386-1897): 0: 589: 97.85		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		170402 SRCAP_HUMAN (1-3230): 0: 1210: 100.00		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Hs
		998717 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Mm
		70929 CHD4_MOUSE (1959-2647): 3.91e-88: 324: 19.80		EP300_MOUSE (1-2426): 0: 867: 53.61
+	Hs
		1059760 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		PHIP_HUMAN (1045-1205): 3.22e-45: 183: 30.36
+	Hs
		1255033 CHD5_HUMAN (1995-2642): 4.91e-88: 324: 19.69		PHIP_HUMAN (1045-1205): 3.22e-45: 183: 30.36
+	Hs
		229448 SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77		PHIP_HUMAN (1045-1205): 3.22e-45: 183: 30.36
+	Hs
		1059944 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83
+	Hs
		1059625 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Hs
		631426 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Hs
		631352 SMCA1_HUMAN (2003-2406): 8.09e-92: 327: 26.49		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Hs
		658677 SMCA1_HUMAN (2003-2406): 8.09e-92: 327: 26.49		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Hs
		229311 SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Hs
		229407 SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Hs
		1059704 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		PB1_HUMAN (1040-1275): 1.29e-12: 76: 14.83
+	Hs
		1017295 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		BPTF_HUMAN (1831-2314): 7.5e-12: 73.6: 11.09
+	Hs
		658659 SMCA1_HUMAN (2003-2406): 8.09e-92: 327: 26.49		BPTF_HUMAN (1831-2314): 7.5e-12: 73.6: 11.09
+	Hs
		1017327 CHD5_HUMAN (1995-2642): 4.91e-88: 324: 19.69		BPTF_HUMAN (1831-2314): 7.5e-12: 73.6: 11.09
+	Hs
		229378 SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77		BPTF_HUMAN (1831-2314): 7.5e-12: 73.6: 11.09