HitPredict

Interactor 1: SRCAP (Q6ZRS2)
Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)
Gene: SRCAP

Interactor 2: H2B1A (Q96A08)
Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)
Gene: H2BC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3230 Hs			1 127
+	Hs
		1087210 SRCAP_HUMAN (1-3230): 0: 1210: 100.00		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		707663 SRCAP_HUMAN (1-3230): 0: 1210: 100.00		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		918462 SRCAP_HUMAN (1-3230): 0: 1210: 100.00		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		1170067 SRCAP_HUMAN (1-3230): 0: 1210: 100.00		H2B3B_HUMAN (1-127): 8.98e-51: 158: 85.83
+	Hs
		1059648 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		1059777 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		H2B1H_HUMAN (5-127): 5.52e-54: 166: 85.37
+	Hs
		241527 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		H2B1K_HUMAN (1-127): 8.56e-54: 166: 84.25
+	Hs
		658684 SMCA1_HUMAN (2003-2406): 8.09e-92: 327: 26.49		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		707635 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		886109 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		H2B1D_HUMAN (1-127): 1.37e-53: 166: 85.04
+	Hs
		918368 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		658646 SMCA1_HUMAN (2003-2406): 8.09e-92: 327: 26.49		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		1059782 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		H2B1A_HUMAN (1-127): 1.72e-52: 163: 100.00
+	Hs
		1059827 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		H2B1L_HUMAN (1-127): 1.35e-52: 163: 85.83
+	Hs
		229415 SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		241591 CHD5_HUMAN (1995-2642): 4.91e-88: 324: 19.69		H2B1K_HUMAN (1-127): 8.56e-54: 166: 84.25
+	Hs
		918541 CHD5_HUMAN (1995-2642): 4.91e-88: 324: 19.69		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		229321 SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		229353 SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		229458 SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77		H2B1H_HUMAN (5-127): 5.52e-54: 166: 85.37