HitPredict

Interactor 1: SRCAP (Q6ZRS2)
Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)
Gene: SRCAP

Interactor 2: ARP6 (Q9GZN1)
Actin-related protein 6 (hArp6) (hARPX)
Gene: ACTR6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~HSA, Actin~SNF2-rel_dom
Common GO terms	GO:0000786 - nucleosome GO:0000812 - Swr1 complex GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3230 Hs			1 396
+	Hs
		891853 SRCAP_HUMAN (1-3230): 0: 1210: 100.00		ACTB_HUMAN (1-393): 0: 520: 26.37
+	Hs
		929905 SRCAP_HUMAN (1-3230): 0: 1210: 100.00		ACTG_HUMAN (1-393): 0: 519: 26.37
+	Hs
		932219 SRCAP_HUMAN (1-3230): 0: 1210: 100.00		ACTC_HUMAN (2-393): 0: 512: 26.93
+	Hs
		891769 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		ACTB_HUMAN (1-393): 0: 520: 26.37
+	Hs
		932158 CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60		ACTC_HUMAN (2-393): 0: 512: 26.93
+	Hs
		229358 SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77		ACTC_HUMAN (2-393): 0: 512: 26.93
+	Zm
		13638 A0A1D6MT91_MAIZE (2011-2412): 6.1e-84: 304: 24.26		A0A1D6FW13_MAIZE (1-393): 0: 512: 26.62
+	Dm
		501486 BRM_DROME (2000-2437): 5.71e-73: 274: 24.32		ACT1_DROME (1-393): 0: 518: 26.12
+	Sc
		887678 SWR1_YEAST (1997-2303): 1.52e-70: 266: 50.81		ACT_YEAST (1-393): 0: 526: 27.11
+	Hs
		892104 INO80_HUMAN (1894-2441): 1.39e-72: 272: 24.19		ACTB_HUMAN (1-393): 0: 520: 26.37
+	Dm
		361138 BRM_DROME (2000-2437): 5.71e-73: 274: 24.32		ACT2_DROME (1-393): 0: 517: 26.37
+	Sc
		859259 INO80_YEAST (1949-2229): 2.19e-63: 242: 32.03		ACT_YEAST (1-393): 0: 526: 27.11
+	Xl
		292752 Q4VQ79_XENLA (2010-2446): 4.54e-65: 248: 23.18		ACTB_XENLA (1-393): 0: 519: 26.37
+	Hs
		846910 SMCA4_HUMAN (1505-1858): 9.38e-13: 76.9: 13.22		ACTB_HUMAN (1-393): 0: 520: 26.37
+	Hs
		846917 SMCA4_HUMAN (1505-1858): 9.38e-13: 76.9: 13.22		ACTG_HUMAN (1-393): 0: 519: 26.37
+	Sp
		142449 SWR1_SCHPO (2039-2346): 3.61e-72: 269: 46.43		ARP6_SCHPO (3-393): 3.76e-96: 294: 39.15
+	At
		1186945 PIE1_ARATH (1893-2597): 1.16e-79: 297: 27.73		ARP6_ARATH (4-394): 5.09e-78: 248: 34.67
+	Sc
		983752 SWR1_YEAST (1997-2303): 1.52e-70: 266: 50.81		ARP6_YEAST (4-390): 2.34e-48: 171: 29.00
+	Sp
		142452 SWR1_SCHPO (2039-2346): 3.61e-72: 269: 46.43		ACT_SCHPO (1-393): 1.6e-46: 165: 26.37
+	Sp
		144858 INO80_SCHPO (1955-2216): 3.12e-57: 223: 33.33		ACT_SCHPO (1-393): 1.6e-46: 165: 26.37