HitPredict

Interactor 1: PHLP2 (Q6ZVD8)
PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)
Gene: PHLPP2

Interactor 2: SNX27 (Q96L92)
Sorting nexin-27
Gene: SNX27

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	27880917, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1323 Hs			1 541
+	Hs
		232963 PHLP1_HUMAN (36-1300): 0: 845: 53.04		SNX27_HUMAN (1-541): 0: 625: 100.00
+	Hs
		1075423 PHLP2_HUMAN (1-1323): 0: 993: 100.00		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		153932 PHLP2_HUMAN (1-1323): 0: 993: 100.00		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		232891 PHLP1_HUMAN (36-1300): 0: 845: 53.04		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		153848 PHLP1_HUMAN (36-1300): 0: 845: 53.04		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		232854 PHLP1_HUMAN (36-1300): 0: 845: 53.04		ZO1_HUMAN (4-254): 7.48e-12: 70.3: 13.97
+	Hs
		1296886 LRRC1_HUMAN (513-772): 7.92e-14: 77.8: 29.83		SNX27_HUMAN (1-541): 0: 625: 100.00
+	Hs
		1298923 LRRC7_HUMAN (448-746): 2.05e-13: 77.4: 28.89		NEB2_HUMAN (40-314): 3.95e-34: 139: 17.98
+	Mm
		1163964 LRRC7_MOUSE (448-746): 2.69e-13: 77: 28.89		NEB2_MOUSE (40-314): 1.09e-33: 138: 17.98
+	Rn
		192524 LRRC7_RAT (448-746): 2.69e-13: 77: 28.89		NEB2_RAT (40-314): 1.07e-33: 138: 17.98
+	Hs
		1298929 LRRC7_HUMAN (448-746): 2.05e-13: 77.4: 28.89		SHAN1_HUMAN (43-169): 7.26e-32: 133: 30.71
+	Hs
		1033831 SCRIB_HUMAN (438-732): 2.62e-12: 73.9: 29.00		SNTA1_HUMAN (1-188): 2.48e-29: 123: 20.10
+	Mm
		1115982 LRRC7_MOUSE (448-746): 2.69e-13: 77: 28.89		SHAN3_MOUSE (44-148): 2.57e-21: 100: 36.19
+	Dm
		677695 SCRIB_DROME (513-779): 9.01e-12: 72.4: 25.51		DLG1_DROME (44-160): 1.73e-12: 72.3: 19.49