HitPredict

Interactor 1: PAXI1 (Q6ZW49)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
Gene: PAXIP1

Interactor 2: SRRM1 (Q8IYB3)
Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)
Gene: SRRM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16159877
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016363 - nuclear matrix
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1069 Hs			1 904
+	Mm
		1157866 PAXI1_MOUSE (592-1069): 2.91e-144: 461: 92.47		KMT2D_MOUSE (185-892): 2.08e-12: 73.8: 9.99
+	Mm
		1157867 PAXI1_MOUSE (592-1069): 2.91e-144: 461: 92.47		KMT2C_MOUSE (113-814): 3.96e-09: 63: 10.86
+	Hs
		1222845 ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97		SRRM1_HUMAN (1-904): 7.55e-73: 259: 100.00
+	Hs
		1056872 PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00		MDC1_HUMAN (204-903): 7.29e-13: 75: 9.61
+	Hs
		1173188 PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00		KMT2C_HUMAN (390-904): 1.47e-09: 64.6: 11.65
+	Hs
		1173280 PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00		SRRM2_HUMAN (189-896): 4.93e-09: 62.6: 13.28
+	Hs
		152660 PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00		KMT2D_HUMAN (365-903): 9.97e-09: 61.9: 12.32
+	Hs
		1056827 MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77		MDC1_HUMAN (204-903): 7.29e-13: 75: 9.61
+	Hs
		1056937 MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77		CHAP1_HUMAN (463-892): 8.67e-10: 64.5: 14.85
+	Hs
		1056991 ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97		MDC1_HUMAN (204-903): 7.29e-13: 75: 9.61
+	Hs
		1262722 ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97		ATX2L_HUMAN (104-788): 2.79e-11: 69.6: 10.35
+	Hs
		1333815 ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97		SRRM2_HUMAN (189-896): 4.93e-09: 62.6: 13.28
+	Mm
		1351630 PCLO_MOUSE (190-871): 4.97e-25: 115: 10.12		PCLO_MOUSE (84-904): 4.87e-24: 111: 9.78
+	Dm
		113995 M9PB30_DROME (150-909): 5.13e-11: 69.7: 8.92		Q9VU43_DROME (6-815): 4.26e-31: 133: 22.40
+	Hs
		1056907 TOPB1_HUMAN (3-336): 2.54e-18: 93.2: 16.86		MDC1_HUMAN (204-903): 7.29e-13: 75: 9.61
+	Hs
		152673 TOPB1_HUMAN (3-336): 2.54e-18: 93.2: 16.86		KMT2D_HUMAN (365-903): 9.97e-09: 61.9: 12.32
+	Dm
		113976 M9PB30_DROME (150-909): 5.13e-11: 69.7: 8.92		M9PB30_DROME (357-903): 1.82e-13: 77.2: 13.36
+	Hs
		152667 KMT2C_HUMAN (162-612): 3.03e-12: 73.5: 9.11		KMT2D_HUMAN (365-903): 9.97e-09: 61.9: 12.32
+	Dm
		113984 M9PB30_DROME (150-909): 5.13e-11: 69.7: 8.92		Q9VC60_DROME (504-842): 6.88e-09: 61.7: 17.73