HitPredict

Interactor 1: PAXI1 (Q6ZW49)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
Gene: PAXIP1

Interactor 2: P121A (Q96HA1)
Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa)
Gene: POM121

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1069 Hs			1 1249
+	Mm
		1157874 PAXI1_MOUSE (592-1069): 2.91e-144: 461: 92.47		NCOA6_MOUSE (22-1120): 1.69e-19: 97.7: 8.89
+	Mm
		1157867 PAXI1_MOUSE (592-1069): 2.91e-144: 461: 92.47		KMT2C_MOUSE (4-816): 5.48e-18: 92.6: 9.58
+	Mm
		1157866 PAXI1_MOUSE (592-1069): 2.91e-144: 461: 92.47		KMT2D_MOUSE (5-1248): 4.79e-09: 63.4: 7.92
+	Hs
		1173188 PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00		KMT2C_HUMAN (570-1226): 5.4e-15: 82.9: 13.37
+	Hs
		1056872 PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00		MDC1_HUMAN (87-1249): 8.98e-14: 78.8: 9.17
+	Hs
		1057766 PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00		NCOA6_HUMAN (362-1248): 1.45e-11: 71.5: 8.61
+	Hs
		1173211 PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		1173280 PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00		SRRM2_HUMAN (3-891): 8.36e-09: 62.5: 10.62
+	Hs
		1056898 MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77		ARI1B_HUMAN (128-1241): 3.11e-14: 80.3: 7.91
+	Hs
		1056827 MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77		MDC1_HUMAN (87-1249): 8.98e-14: 78.8: 9.17
+	Hs
		858054 ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97		NUP98_HUMAN (828-1223): 9.68e-19: 95.1: 19.77
+	Hs
		1056991 ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97		MDC1_HUMAN (87-1249): 8.98e-14: 78.8: 9.17
+	Hs
		1333815 ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97		SRRM2_HUMAN (3-891): 8.36e-09: 62.5: 10.62
+	Hs
		1300971 CHD7_HUMAN (188-893): 7.26e-34: 144: 9.07		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Mm
		1351630 PCLO_MOUSE (190-871): 4.97e-25: 115: 10.12		PCLO_MOUSE (772-1247): 3.08e-16: 86.9: 7.35
+	Hs
		1056907 TOPB1_HUMAN (3-336): 2.54e-18: 93.2: 16.86		MDC1_HUMAN (87-1249): 8.98e-14: 78.8: 9.17
+	Dm
		113976 M9PB30_DROME (150-909): 5.13e-11: 69.7: 8.92		M9PB30_DROME (16-578): 1.73e-15: 84.6: 8.44
+	Hs
		1057773 KMT2C_HUMAN (162-612): 3.03e-12: 73.5: 9.11		NCOA6_HUMAN (362-1248): 1.45e-11: 71.5: 8.61
+	Hs
		867119 SC24C_HUMAN (182-460): 3.09e-12: 73.2: 8.84		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		300546 NFAT5_HUMAN (180-600): 4.53e-12: 72.7: 15.29		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81