HitPredict

Interactor 1: MD13L (Q71F56)
Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)
Gene: MED13L

Interactor 2: MED4 (Q9NPJ6)
Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)
Gene: MED4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	25281560, 24981860, 33961781, 35271311, 36950384
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003712 - transcription coregulator activity GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0016592 - mediator complex
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 2210 Hs			1 270
+	Hs
		1342940 MED13_HUMAN (4-2210): 0: 3181: 51.34		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00
+	Dm
		1182303 MED13_DROME (943-1152): 8.63e-10: 66.7: 23.77		MED4_DROME (25-258): 6.66e-90: 268: 39.68