HitPredict

Interactor 1: SKP1 (Q71U00)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Interactor 2: TRCB (Q91854)
Beta-TrCP (Beta-transducin repeat-containing protein)
Gene: fbxw1

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	10339577
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Xl			1 518
+	Sp
		1000009 SKP1_SCHPO (1-163): 6.54e-73: 217: 56.36		POF11_SCHPO (20-514): 5.64e-90: 286: 26.79
+	Mm
		1257397 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBXW7_MOUSE (36-416): 2.26e-72: 245: 20.61
+	Hs
		929021 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXW7_HUMAN (36-416): 1.58e-71: 243: 20.61
+	Dm
		218244 O77430_DROME (1-163): 1.01e-79: 235: 76.69		O44382_DROME (312-517): 1.85e-54: 192: 32.54
+	Dm
		285012 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VDE3_DROME (312-517): 2.52e-54: 192: 32.54
+	Hs
		245588 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		TBL1X_HUMAN (54-384): 3.12e-46: 172: 14.01
+	Dm
		1180601 Q7KJ69_DROME (1-163): 1.92e-74: 221: 67.49		Q9VDE3_DROME (312-517): 2.52e-54: 192: 32.54
+	Dm
		285042 O77430_DROME (1-163): 1.01e-79: 235: 76.69		FBXW7_DROME (341-517): 2.5e-47: 178: 33.71
+	Sp
		144900 SKP1_SCHPO (1-163): 6.54e-73: 217: 56.36		POP2_SCHPO (128-411): 1.43e-50: 185: 17.09
+	Ce
		105997 G5EDD8_CAEEL (4-162): 1.84e-65: 199: 60.25		LIN23_CAEEL (312-517): 6.63e-55: 197: 30.62
+	Hs
		928956 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		TRAF7_HUMAN (345-517): 1.19e-29: 125: 27.27
+	Sp
		953235 SKP1_SCHPO (1-163): 6.54e-73: 217: 56.36		POP1_SCHPO (155-420): 1.52e-41: 160: 19.59
+	Sp
		953229 SKP1_SCHPO (1-163): 6.54e-73: 217: 56.36		POF1_SCHPO (1-350): 7.52e-40: 154: 15.86
+	Sc
		431143 SKP1_YEAST (2-163): 5.85e-65: 198: 42.19		CDC4_YEAST (155-451): 5.1e-43: 165: 18.97
+	Hs
		929116 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXW2_HUMAN (388-517): 1.49e-24: 108: 25.00
+	Ce
		105479 SKR1_CAEEL (4-162): 2.25e-78: 232: 70.81		SEL10_CAEEL (389-518): 1.32e-27: 118: 31.58
+	Mm
		1131317 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBW1B_MOUSE (423-517): 1.45e-15: 81.1: 30.53
+	Hs
		929110 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBW1B_HUMAN (423-517): 2.08e-15: 80.7: 30.53
+	Hs
		929125 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBW1A_HUMAN (423-517): 2.47e-15: 80.7: 30.53
+	Mm
		1112932 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBW1A_MOUSE (423-517): 1.24e-14: 78.4: 30.53