HitPredict

Interactor 1: MYO1C (O00159)
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
Gene: MYO1C

Interactor 2: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27545878
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045121 - membrane raft GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0071346 - cellular response to type II interferon
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1063 Hs			1 233
+	Hs
		297264 MYO1D_HUMAN (45-1056): 0: 1076: 39.87		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Hs
		214460 MYO1B_HUMAN (46-1058): 0: 1058: 39.77		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Hs
		352730 MYO5A_HUMAN (11-1020): 0: 1049: 28.73		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00
+	Hs
		352510 MYH9_HUMAN (5-974): 0: 994: 29.37		TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00