HitPredict

Interactor 1: MYO1C (O00159)
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
Gene: MYO1C

Interactor 2: TWF1 (Q12792)
Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)
Gene: TWF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0015629 - actin cytoskeleton GO:0032587 - ruffle membrane and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1063 Hs			1 350
+	Hs
		117729 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		TWF2_HUMAN (1-344): 3.79e-159: 451: 65.41
+	Hs
		724797 MYH9_HUMAN (5-974): 0: 994: 29.37		TWF1_HUMAN (1-350): 5.66e-171: 481: 100.00
+	Hs
		724875 MYH9_HUMAN (5-974): 0: 994: 29.37		TWF2_HUMAN (1-344): 3.79e-159: 451: 65.41
+	Hs
		117648 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		DEST_HUMAN (4-138): 2.63e-40: 141: 18.59
+	Hs
		117865 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		COF2_HUMAN (4-138): 2.83e-38: 136: 17.53
+	Hs
		117589 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		COF1_HUMAN (4-142): 6.84e-37: 132: 17.09
+	Hs
		724739 MYH9_HUMAN (5-974): 0: 994: 29.37		DEST_HUMAN (4-138): 2.63e-40: 141: 18.59
+	Hs
		725077 MYH9_HUMAN (5-974): 0: 994: 29.37		COF2_HUMAN (4-138): 2.83e-38: 136: 17.53
+	Hs
		618006 MYH9_HUMAN (5-974): 0: 994: 29.37		COF1_HUMAN (4-142): 6.84e-37: 132: 17.09