HitPredict

Interactor 1: MYO1C (O00159)
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
Gene: MYO1C

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~IQ, EF-hand_7~Myosin_head, Myosin_head~Spectrin, EF-hand_7~Myosin_TH1
Common GO terms	GO:0005516 - calmodulin binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0051015 - actin filament binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1063 Hs			1 2472
+	Hs
		522612 MYH7_HUMAN (4-1060): 0: 1068: 27.29		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		724817 MYH9_HUMAN (5-974): 0: 994: 29.37		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		117513 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		117664 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		117521 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		164575 MYH9_HUMAN (5-974): 0: 994: 29.37		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		724781 MYH9_HUMAN (5-974): 0: 994: 29.37		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		724786 MYH9_HUMAN (5-974): 0: 994: 29.37		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		724839 MYH9_HUMAN (5-974): 0: 994: 29.37		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		211432 MYO1B_HUMAN (46-1058): 0: 1058: 39.77		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		110636 MYH9_HUMAN (5-974): 0: 994: 29.37		H3BPE1_HUMAN (9-1261): 4.01e-18: 94.7: 12.35
+	Hs
		725073 MYH9_HUMAN (5-974): 0: 994: 29.37		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		521484 MYH9_HUMAN (5-974): 0: 994: 29.37		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		724994 MYH9_HUMAN (5-974): 0: 994: 29.37		CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94
+	Hs
		211515 MYH9_HUMAN (5-974): 0: 994: 29.37		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15