HitPredict

Interactor 1: Q7K148 (Q7K148)
Proteasome subunit beta
Gene: Prosbeta5

Interactor 2: PSDE (Q9V3H2)
26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory complex subunit p37B) (26S proteasome regulatory subunit rpn11) (Yippee-interacting protein 5)
Gene: Rpn11

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	22036573, 19079254
Identification Methods	affinity chromatography technology, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 282 Dm			1 308
+	Dm
		1278634 PSA5_DROME (41-273): 2.51e-87: 262: 17.55		PSDE_DROME (1-308): 1.38e-110: 324: 100.00
+	Hs
		130757 PSB5_HUMAN (1-273): 8.79e-89: 266: 52.38		PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69
+	Hs
		130754 PSA5_HUMAN (41-272): 1.3e-88: 265: 18.60		PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69
+	Sp
		784781 PSA5_SCHPO (41-278): 2.84e-90: 269: 18.15		RPN11_SCHPO (1-307): 1.77e-101: 301: 67.21
+	Sp
		784767 PSA3_SCHPO (43-278): 9.22e-88: 263: 16.60		RPN11_SCHPO (1-307): 1.77e-101: 301: 67.21
+	Hs
		130644 PSA7_HUMAN (46-269): 2.53e-85: 257: 15.95		PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69
+	Hs
		130749 PSA4_HUMAN (43-269): 9.16e-85: 256: 17.30		PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69
+	Sp
		675389 PSB5_SCHPO (46-277): 2.52e-80: 245: 53.88		RPN11_SCHPO (1-307): 1.77e-101: 301: 67.21
+	Sp
		784769 PSB2_SCHPO (72-255): 2.42e-79: 242: 33.15		RPN11_SCHPO (1-307): 1.77e-101: 301: 67.21
+	Sc
		675425 PSB5_YEAST (31-275): 6.3e-90: 270: 52.03		RPN11_YEAST (1-308): 2.9e-89: 270: 63.96
+	Sc
		689189 PSA5_YEAST (41-282): 1.61e-84: 255: 21.34		RPN11_YEAST (1-308): 2.9e-89: 270: 63.96
+	Sc
		625944 PSB2_YEAST (72-253): 1.72e-78: 240: 30.77		RPN11_YEAST (1-308): 2.9e-89: 270: 63.96
+	Dm
		640771 Q7K148_DROME (1-282): 5.42e-104: 305: 100.00		PSMD7_DROME (25-306): 4.42e-60: 196: 14.83
+	Hs
		156334 PSA7_HUMAN (46-269): 2.53e-85: 257: 15.95		CSN5_HUMAN (1-305): 2e-73: 230: 30.70
+	Hs
		656177 PSA5_HUMAN (41-272): 1.3e-88: 265: 18.60		PSMD7_HUMAN (26-306): 2.48e-60: 197: 16.96
+	Dm
		640776 PSA5_DROME (41-273): 2.51e-87: 262: 17.55		PSMD7_DROME (25-306): 4.42e-60: 196: 14.83
+	Hs
		638089 PSA4_HUMAN (43-269): 9.16e-85: 256: 17.30		PSMD7_HUMAN (26-306): 2.48e-60: 197: 16.96
+	Sc
		675445 PSB5_YEAST (31-275): 6.3e-90: 270: 52.03		RPN8_YEAST (27-147): 5.77e-12: 67.1: 27.56
+	Sc
		689214 PSA5_YEAST (41-282): 1.61e-84: 255: 21.34		RPN8_YEAST (27-147): 5.77e-12: 67.1: 27.56
+	Sc
		625961 PSB2_YEAST (72-253): 1.72e-78: 240: 30.77		RPN8_YEAST (27-147): 5.77e-12: 67.1: 27.56