HitPredict

Interactor 1: SNP23 (O00161)
Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23)
Gene: SNAP23

Interactor 2: STX6 (O43752)
Syntaxin-6
Gene: STX6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	11001914, 26186194, 34079125, 35271311
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0019905 - syntaxin binding GO:0031201 - SNARE complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 211 Hs			1 255
+	Hs
		212707 SNP29_HUMAN (7-208): 1.02e-56: 181: 21.20		STX6_HUMAN (1-239): 4.31e-68: 212: 100.00
+	Dm
		1177085 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		Q7JRF1_DROME (1-255): 1.23e-62: 200: 40.06
+	Rn
		893313 SNP25_RAT (6-211): 2.27e-55: 176: 59.71		STX6_RAT (1-240): 3.24e-69: 215: 95.42
+	Hs
		235134 SNP29_HUMAN (7-208): 1.02e-56: 181: 21.20		STX10_HUMAN (1-239): 5.84e-67: 209: 61.09
+	Hs
		117928 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		BET1_HUMAN (138-255): 1.8e-33: 119: 16.95
+	Hs
		320445 SNP29_HUMAN (7-208): 1.02e-56: 181: 21.20		STX8_HUMAN (3-236): 1.15e-36: 131: 17.45
+	Hs
		169351 SNP29_HUMAN (7-208): 1.02e-56: 181: 21.20		BET1_HUMAN (138-255): 1.8e-33: 119: 16.95
+	Dm
		1366726 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		Q9VV76_DROME (32-241): 4.95e-26: 103: 14.29
+	Dm
		739436 SNP25_DROME (6-210): 1.87e-57: 182: 50.24		Q9VV76_DROME (32-241): 4.95e-26: 103: 14.29
+	Dm
		1366727 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		Q9VVX6_DROME (142-255): 8.05e-22: 89.2: 21.93
+	Dm
		739437 SNP25_DROME (6-210): 1.87e-57: 182: 50.24		Q9VVX6_DROME (142-255): 8.05e-22: 89.2: 21.93
+	Dm
		1374683 Q9W1I8_DROME (9-210): 3.65e-48: 161: 23.36		Q9VV76_DROME (32-241): 4.95e-26: 103: 14.29
+	Zm
		37691 A0A1D6MBX4_MAIZE (90-207): 5.36e-26: 102: 20.34		A0A1D6MBX4_MAIZE (1-255): 5.51e-44: 151: 17.12
+	Dm
		1374917 Q9W1I8_DROME (9-210): 3.65e-48: 161: 23.36		Q9VVX6_DROME (142-255): 8.05e-22: 89.2: 21.93
+	Sc
		772545 SEC9_YEAST (5-205): 7.87e-35: 131: 20.18		TLG1_YEAST (2-238): 4.64e-31: 116: 16.46
+	At
		1277895 SYP71_ARATH (90-206): 2.32e-25: 101: 20.51		BET12_ARATH (129-255): 1.93e-26: 101: 19.69