HitPredict

Interactor 1: SNP23 (O00161)
Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23)
Gene: SNAP23

Interactor 2: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.710

Property	Details
Experiments	16189514, 30833792, 33961781, 35271311
Identification Methods	two hybrid, affinity chromatography technology, two hybrid pooling approach, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016082 - synaptic vesicle priming GO:0019905 - syntaxin binding GO:0061025 - membrane fusion GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 211 Hs			1 295
+	Hs
		118076 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		66337 A8K287_HUMAN (1-211): 1.06e-71: 218: 100.00		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		320285 SNP29_HUMAN (7-208): 1.02e-56: 181: 21.20		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		320411 SNP29_HUMAN (7-208): 1.02e-56: 181: 21.20		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		873525 SNP25_HUMAN (6-211): 2.27e-55: 176: 59.71		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Dm
		1095577 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Dm
		739418 SNP25_DROME (6-210): 1.87e-57: 182: 50.24		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Dm
		1095590 Q9W1I8_DROME (9-210): 3.65e-48: 161: 23.36		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Sc
		696576 SEC9_YEAST (5-205): 7.87e-35: 131: 20.18		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Hs
		320397 SNP29_HUMAN (7-208): 1.02e-56: 181: 21.20		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		1353742 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		739428 SNP25_DROME (6-210): 1.87e-57: 182: 50.24		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1366623 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53
+	Dm
		739431 SNP25_DROME (6-210): 1.87e-57: 182: 50.24		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53
+	Dm
		1353754 Q9W1I8_DROME (9-210): 3.65e-48: 161: 23.36		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1366631 Q9W1I8_DROME (9-210): 3.65e-48: 161: 23.36		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53