HitPredict

Interactor 1: Q7K4D1 (Q7K4D1)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Gene: POSH

Interactor 2: Q9VB05 (Q9VB05)
ALG-2 interacting protein X (LD25543p)
Gene: ALiX

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	16698022
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0046330 - positive regulation of JNK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 838 Dm			1 836
+	Dm
		1342129 Q9NHP2_DROME (1-838): 2.18e-133: 420: 99.76		Q9VB05_DROME (1-836): 0: 576: 100.00
+	Hs
		1260385 SH3G1_HUMAN (70-197): 1.68e-36: 143: 29.86		PDC6I_HUMAN (1-831): 1.81e-177: 535: 40.28
+	Mm
		1143918 SH3G1_MOUSE (82-197): 6.23e-38: 147: 31.06		PDC6I_MOUSE (1-831): 7.33e-168: 510: 39.89
+	Hs
		1191850 SH3R1_HUMAN (365-836): 2.59e-21: 101: 14.20		PDC6I_HUMAN (1-831): 1.81e-177: 535: 40.28
+	Hs
		1078881 ITSN1_HUMAN (48-202): 7.34e-17: 88: 18.07		PDC6I_HUMAN (1-831): 1.81e-177: 535: 40.28
+	Hs
		1260386 SH3G2_HUMAN (193-254): 7.93e-16: 81.9: 38.71		PDC6I_HUMAN (1-831): 1.81e-177: 535: 40.28
+	Hs
		924726 GRB2_HUMAN (419-481): 2.7e-16: 80.7: 33.33		PDC6I_HUMAN (1-831): 1.81e-177: 535: 40.28
+	Mm
		1143926 SH3G2_MOUSE (193-254): 5.31e-16: 82.3: 38.71		PDC6I_MOUSE (1-831): 7.33e-168: 510: 39.89
+	Mm
		1141174 GRB2_MOUSE (416-481): 2.55e-16: 80.7: 31.82		PDC6I_MOUSE (1-831): 7.33e-168: 510: 39.89
+	Ce
		104698 SRBS1_CAEEL (613-835): 8.31e-22: 103: 17.49		ALXA_CAEEL (4-831): 6.57e-152: 469: 37.01
+	Hs
		1078907 ITSN1_HUMAN (48-202): 7.34e-17: 88: 18.07		PTN23_HUMAN (3-833): 8.29e-127: 418: 22.46
+	Hs
		1307434 SH3G2_HUMAN (193-254): 7.93e-16: 81.9: 38.71		PTN23_HUMAN (3-833): 8.29e-127: 418: 22.46
+	Hs
		275227 GRAP2_HUMAN (765-836): 7.7e-16: 81.5: 25.00		PTN23_HUMAN (3-833): 8.29e-127: 418: 22.46
+	Hs
		924858 GRB2_HUMAN (419-481): 2.7e-16: 80.7: 33.33		PTN23_HUMAN (3-833): 8.29e-127: 418: 22.46
+	Mm
		292687 GRAP2_MOUSE (50-194): 2.58e-16: 83: 17.24		PTN23_MOUSE (3-829): 1.28e-121: 404: 21.38
+	Hs
		978569 SH3G1_HUMAN (70-197): 1.68e-36: 143: 29.86		PRB3_HUMAN (699-834): 2.22e-13: 74.5: 16.67
+	Hs
		235528 VINEX_HUMAN (273-836): 2.28e-17: 89: 11.86		PKHA7_HUMAN (576-832): 2.31e-29: 128: 16.54
+	Hs
		924640 GRB2_HUMAN (419-481): 2.7e-16: 80.7: 33.33		PKHA7_HUMAN (576-832): 2.31e-29: 128: 16.54
+	Hs
		1073686 SH3R1_HUMAN (365-836): 2.59e-21: 101: 14.20		SF3A2_HUMAN (710-832): 1.44e-13: 76.1: 13.71
+	Hs
		924592 GRB2_HUMAN (419-481): 2.7e-16: 80.7: 33.33		SF3A2_HUMAN (710-832): 1.44e-13: 76.1: 13.71