HitPredict

Interactor 1: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	21513698, 19615732, 29089450, 22072711
Identification Methods	affinity chromatography technology, enzymatic study, pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 788 Hs			1 986
+	Hs
		647940 MARK3_HUMAN (3-788): 0: 656: 60.40		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Hs
		1273263 MARK4_HUMAN (3-788): 0: 572: 48.20		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Hs
		647880 MARK3_HUMAN (3-788): 0: 656: 60.40		AKP13_HUMAN (37-964): 2.77e-144: 478: 35.95
+	Mm
		1149072 BRSK2_MOUSE (34-481): 8.59e-138: 426: 36.60		ARHG7_MOUSE (22-851): 9.73e-95: 321: 12.00