HitPredict

Interactor 1: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 258 Hs			1 975
+	Hs
		436457 RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		1183506 RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		892540 RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		951237 RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		925520 RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		900802 RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		125100 RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125541 RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125294 RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125372 RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		808080 RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125349 RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125308 RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		925397 RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		925423 RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76		HACE1_HUMAN (463-968): 7.94e-168: 516: 33.53
+	Hs
		914199 RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87		HACE1_HUMAN (463-968): 7.94e-168: 516: 33.53
+	Mm
		56825 RAC1_MOUSE (50-234): 2.11e-79: 239: 56.76		SMUF2_MOUSE (21-324): 1.92e-29: 128: 22.56
+	Hs
		900929 RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		900923 RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Rn
		88544 RHOA_RAT (51-232): 1.24e-77: 234: 46.15		D3ZCF5_RAT (37-365): 1.89e-21: 102: 15.73