HitPredict

Interactor 1: DOK3 (Q7L591)
Docking protein 3 (Downstream of tyrosine kinase 3)
Gene: DOK3

Interactor 2: DOK5 (Q9P104)
Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)
Gene: DOK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	IRS~IRS
Common GO terms	GO:0005737 - cytoplasm GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0007265 - Ras protein signal transduction GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 496 Hs			1 306
+	Hs
		1184730 DOK3_HUMAN (1-496): 0: 539: 100.00		DOK4_HUMAN (1-298): 9.29e-119: 346: 60.33
+	Hs
		235088 DOK3_HUMAN (1-496): 0: 539: 100.00		DOK2_HUMAN (6-268): 2.63e-76: 240: 22.42
+	Hs
		1184737 DOK3_HUMAN (1-496): 0: 539: 100.00		DOK1_HUMAN (6-264): 5.18e-72: 231: 22.59
+	Hs
		1184725 DOK3_HUMAN (1-496): 0: 539: 100.00		DOK3_HUMAN (9-267): 4.7e-65: 213: 19.73
+	Mm
		250952 DOK1_MOUSE (60-491): 4.19e-125: 375: 30.19		DOK2_MOUSE (6-292): 1.38e-75: 238: 20.85
+	Hs
		235099 DOK1_HUMAN (60-491): 1.13e-123: 371: 29.92		DOK2_HUMAN (6-268): 2.63e-76: 240: 22.42
+	Hs
		1305736 DOK1_HUMAN (60-491): 1.13e-123: 371: 29.92		DOK1_HUMAN (6-264): 5.18e-72: 231: 22.59
+	Hs
		235025 DOK2_HUMAN (61-455): 2.1e-95: 296: 34.04		DOK2_HUMAN (6-268): 2.63e-76: 240: 22.42
+	Mm
		724590 IRS1_MOUSE (65-494): 2.12e-87: 293: 15.32		IRS2_MOUSE (8-304): 1.1e-65: 225: 16.86
+	Hs
		724515 IRS1_HUMAN (65-494): 2.85e-88: 296: 15.58		IRS1_HUMAN (2-304): 2.19e-61: 212: 19.34
+	Hs
		207284 FRS3_HUMAN (198-454): 5.09e-51: 182: 20.58		FRS3_HUMAN (126-303): 7.07e-42: 152: 20.79