HitPredict

Interactor 1: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Interactor 2: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 26186194, 28514442, 27173435, 32034103, 33961781, 19615732, 21145461, 19295130, 21625211, 25144743, 31950832, 18850735, 19141280, 25043011, 20399188
Identification Methods affinity chromatography technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CSN5_C~JAB, JAB~JAB, CSN5_C~MitMem_reg, JAB~MitMem_reg
Common GO terms GO:0000338 - protein deneddylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 327
Hs

1 334
+ Mm
+ Dm
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+ At
+ At
+ At
+ At
+ At
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce
+ Hs
+ Sc
+ Sp
+ Dm
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024