HitPredict

Interactor 1: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	31253590, 33961781, 21145461, 19615732, 19295130
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~JAB
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 327 Hs			1 780
+	Hs
		1041897 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		1041064 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		CUL1_HUMAN (11-780): 0: 748: 27.84
+	Hs
		1043079 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		1043429 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		91398 E7EM64_HUMAN (1-327): 1.07e-139: 399: 99.69		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		1041373 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		CUL2_HUMAN (6-780): 0: 699: 26.36
+	Hs
		124855 EIF3F_HUMAN (10-306): 1.15e-110: 327: 22.07		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		849195 PSMD7_HUMAN (37-317): 1.48e-97: 292: 24.48		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		177020 EIF3H_HUMAN (33-305): 9.03e-59: 194: 14.38		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Ce
		954204 CSN5_CAEEL (29-253): 1.44e-51: 176: 11.95		CUL3_CAEEL (17-780): 0: 658: 21.47