HitPredict

Interactor 1: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Interactor 2: BTBD2 (Q9BX70)
BTB/POZ domain-containing protein 2
Gene: BTBD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.739

Property	Details
Experiments	16169070, 26186194, 28514442, 33961781, 19615732, 21145461
Identification Methods	two hybrid, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 327 Hs			1 525
+	Hs
		1184976 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		BTBD1_HUMAN (89-525): 1.79e-112: 344: 81.94
+	Hs
		1121474 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		KLH26_HUMAN (100-402): 2.27e-79: 261: 25.57
+	Hs
		1120774 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		KLH12_HUMAN (366-517): 3.53e-30: 126: 9.80
+	Hs
		1185018 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		KLH20_HUMAN (365-515): 3.22e-26: 114: 9.21
+	Hs
		1184999 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		KLHL9_HUMAN (334-514): 2.28e-24: 108: 6.52
+	Hs
		1185001 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		KLH13_HUMAN (366-514): 1.89e-23: 106: 7.90
+	Hs
		299521 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		KLH18_HUMAN (94-521): 1.49e-23: 106: 11.16
+	Hs
		1184948 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		BTBD9_HUMAN (103-337): 6.1e-23: 104: 29.58
+	Hs
		1153783 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		KLH10_HUMAN (328-517): 1.11e-22: 103: 7.33
+	Hs
		1164611 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		KLH24_HUMAN (321-515): 8e-19: 91.8: 11.33
+	Hs
		1184998 CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00		KLHL8_HUMAN (365-460): 1.17e-13: 75.7: 13.40