HitPredict

Interactor 1: MAEA (Q7L5Y9)
E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP)
Gene: MAEA

Interactor 2: GID4 (Q8IVV7)
Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog)
Gene: GID4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	27173435, 29911972
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0034657 - GID complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 396 Hs			1 300
+	Hs
		1218043 RMD5A_HUMAN (21-395): 8.17e-121: 357: 20.41		GID4_HUMAN (1-300): 3.35e-161: 452: 100.00
+	Hs
		1218047 GID8_HUMAN (101-284): 3.5e-47: 162: 20.32		GID4_HUMAN (1-300): 3.35e-161: 452: 100.00
+	Hs
		1218034 RANB9_HUMAN (116-215): 3.98e-25: 109: 17.00		GID4_HUMAN (1-300): 3.35e-161: 452: 100.00
+	Hs
		1167150 RBP10_HUMAN (114-215): 1.14e-23: 104: 15.69		GID4_HUMAN (1-300): 3.35e-161: 452: 100.00
+	Sc
		747300 RMD5_YEAST (27-396): 4.87e-76: 243: 15.48		GID4_YEAST (102-299): 3.45e-63: 205: 27.80
+	Sc
		858896 VID30_YEAST (122-313): 1.1e-29: 123: 10.78		YG29_YEAST (121-290): 5.49e-72: 225: 30.35
+	Sc
		747287 VID30_YEAST (122-313): 1.1e-29: 123: 10.78		GID4_YEAST (102-299): 3.45e-63: 205: 27.80
+	Sc
		747273 FYV10_YEAST (254-394): 6.39e-20: 93.3: 25.56		GID4_YEAST (102-299): 3.45e-63: 205: 27.80