HitPredict

Interactor 1: MAEA (Q7L5Y9)
E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP)
Gene: MAEA

Interactor 2: GDF15 (Q99988)
Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)
Gene: GDF15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 396 Hs			1 308
+	Hs
		1307545 RMD5A_HUMAN (21-395): 8.17e-121: 357: 20.41		GDF15_HUMAN (1-308): 6.47e-102: 302: 100.00
+	Hs
		1291935 RMD5B_HUMAN (20-395): 5.6e-116: 345: 20.00		GDF15_HUMAN (1-308): 6.47e-102: 302: 100.00
+	Hs
		351454 RMD5A_HUMAN (21-395): 8.17e-121: 357: 20.41		TGFB1_HUMAN (33-307): 7.59e-61: 200: 21.48
+	Hs
		1307547 GID8_HUMAN (101-284): 3.5e-47: 162: 20.32		GDF15_HUMAN (1-308): 6.47e-102: 302: 100.00
+	Hs
		1301766 RANB9_HUMAN (116-215): 3.98e-25: 109: 17.00		GDF15_HUMAN (1-308): 6.47e-102: 302: 100.00
+	Hs
		1167170 RBP10_HUMAN (114-215): 1.14e-23: 104: 15.69		GDF15_HUMAN (1-308): 6.47e-102: 302: 100.00
+	Hs
		351441 RANB9_HUMAN (116-215): 3.98e-25: 109: 17.00		TGFB1_HUMAN (33-307): 7.59e-61: 200: 21.48