HitPredict

Interactor 1: MAEA (Q7L5Y9)
E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP)
Gene: MAEA

Interactor 2: GID8 (Q9NWU2)
Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1)
Gene: GID8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.917

The method score is based on:

Property Details
Experiments 29911972, 27173435, 33961781, 17467196
Identification Methods affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CTLH~CTLH, CTLH~LisH
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 396
Hs

1 228
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024